Cell scientist to watch - Mahak Sharma.

Nevus Lipomatosus Cutaneous Superficialis with Unusual Presentation over the Nipple

Amyloid Precursor-Like Protein 2 Increases the Endocytosis, Instability, and Turnover of the H2-K MHC Class I Molecule

Lysosomal Trafficking, Antigen Presentation, and Microbial Killing Are Controlled by the Arf-like GTPase Arl8b

Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf-like GTPase Arl8b as a critical regulator of cargo delivery to lysosomes. Hom...

Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule.

The defense against the invasion of viruses and tumors relies on the presentation of viral and tumor-derived peptides to CTL by cell surface MHC class I molecules. Previously, we showed that the ubiquitously expressed protein amyloid precursor-like protein 2 (APLP2) associates with the folded form of the MHC class I molecule K(d). In the current study, APLP2 was found to associate with folded K...

Cell scientist to watch - Megan King.

Megan king received her BA in biochemistry from Brandeis University and then pursued a PhD degree in Biochemistry and Molecular Biophysics at the University of Pennsylvania working in the group of Mark Lemmon. For her postdoctoral training, Megan chose the laboratory of Günter Blobel at the Rockefeller University in New York. Since starting her own group at the Cell Biology Department at Yale S...